I don't think so. She is nowhere nearly as evil as any of the incarnations of Ghidra (or ghidora, or king ghidora, different variations). Destroyah, she's pretty brutal, but I'm sure that she is not entirely evil. Junior attacked her, and she had no knowledge of the Godzilla species, and thus had no idea that he was a child. He also did some serious damage to one of her smaller, weaker stages, and obviously would not take kindly to that. Ghidra on the other hand, would go out of his way to wipe out entire sapient (human level) species for fun, thus earning the title of "destroyer of worlds". You could argue Hedorah, but I think he's a vaguely intelligent virus. Ghidora is an evil shit-fuck, thus, he is the most evil monster in the Godzilla franchise. Destroyah was acting in self defense. And her smaller stages that fought those guys in that building? Less intelligent, until forming a larger, more intelligent stage. Besides, what happens when you intrude in a wolf packs territory?
I dunno, Destoroyah cackled when he killed Goji Jr. and laughed at Godzilla Sr. when he started to mourn his death. Ghidorah is more of a nihllist, while Destoroyah looks more like a sadist. At least that's what I've figured.